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Unlike other nootropics on the market, a CILTEP stack works inside the cell to naturally induce Long-Term Potentiation (LTP), a state of increased neuron connectivity.
For biohackers, here are the primary mechanisms by which CILTEP induces LTPLong-Term Potentiation (LTP) is a long-lasting enhancement in signal transmission between two neurons that results from stimulating them both at the same time. LTP is one of the major cellular mechanisms behind learning and memory. Memories are formed or 'encoded' in the brain by creating LTP.ARTSKOLIN achieves LTP by: 1. Inhibiting Phosphodiesterase-4 (PDE4), and 2. Increasing cyclic adenosine monophosphate (cAMP).
1. PDE4 InhibitionPDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain.Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells. PDE4 inhibitors have been shown to have significant nootropic effects including increased cognition , improved long term memory, increased wakefulness, and neuroprotection.
Artichoke Extract is known to be the safest and most effective PDE4 Inhibitor.There are other herbal supplements that can also perform PDE4 Inhibition but they have all been found to have significant side effects. CILTEP has 900 mg of high quality Artichoke Extract in each serving.
2. Increasing cAMP
An herbal supplement named Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) is the only known supplement to naturally increase cAMP levels. It has been used for thousands of years in traditional Indian Aryuvedic medicine. Forskolin activates the enzyme adenylyl cyclase which increases intracellular levels of cAMP.CILTEP features premium Coleus Forskohlii that is standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.
Increasing cAMP and inhibiting its degradation (through PDE4 Inhibition) induces Long-Term Potentiation (LTP). The result is an overall improvement of cognitive function, especially memory formation and retention of new information.
LTP & Dopamine
This regimen makes normal dopamine metabolism more effective at triggering the motivation, learning, and memory processes. Meanwhile, the chemical dynamics of the dopamine system are preserved, which avoids all negative side effects associated with using traditional dopamine stimulation (such as Adderall or Ritalin).
Research has shown that increased intracellular cAMP increases the rate of dopamine synthesis. We include Vitamin B6 and the natural dopamine precursor L-Phenylalanine to the CILTEP formula to keep your brain well stocked with the building blocks of dopamine. L-Phenylalanine (pronounced feen-ull-AL-uh-neen) is an amino acid found in some foods that the brain uses to make dopamine and it synergizes perfectly with Artichoke Extract and Forskolin, reducing fatigue and creating long lasting results with a lift in mood