Are you working to reduce fatigue, anxiety, and brain fog? Do you want your thoughts to be smoother and more productive? Do you want to supercharge your brain for better learning and faster thinking without the side effects of stimulants? That’s a big part of learning to be in the Bulletproof state of high performance. It’s something we strive for every day, always seeking new ways to do more.
After years of testing, Upgraded Self is excited to introduce a new substance that has risen above the rest as a safe, effective way to Bulletproof your brain: oxaloacetate, also known as OAA.
Shown to protect neurons in the brain from environmental toxins, OAA can also improve day-to-day brain function and may even help reduce age related conditions. There is also compelling evidence that it can improve short term memory, as well as increasing the quantity and quality of life.
Oxaloacetate is an anti-aging formula every Bulletproof person should consider for quality and length of life. Here’s why:
- It’s a nutritional supplement, not a drug. Oxaloacetate is found in many foods, and it’s a critical metabolic compound in your body.
- This stuff has scientifically verified research behind it. A lot of scientifically verified research.
- Our main recommendation for oxaloacetate is to upgrade your brain. Clear out that brain fog, stop repetitive/circular thoughts that slow you down and crystallize your real cognitive potential.
Our oxaloacetate is from an extremely high quality source where impurities are ruthlessly flushed out and removed. You won’t get a ton of low quality fillers and stabilizers like you would from other supplements. And being thermally stabilized, you don’t have to store it at -40 degrees C.
Upgraded Aging Formula vegi-caps are 100%soy-free, gluten-free, sugar-free, and contain no colorants, no flow agents, and no preservatives.
Our oxaloacetate is in a form that is easily assimilated by your body, so it actually does its job and doesn’t just come out as expensive urine. It’s water soluble, and PKA studies show it in the bloodstream 30 minutes after ingestion.
Our main recommendation for oxaloacetate is to upgrade your brain. Clear out that brain fog, stop repetitive/circular thoughts that slow you down, and crystallize your real cognitive potential. There are 250mg of Upgraded Aging Formula in each capsule, and 30 capsules in 1 bottle. 100mg of each capsule is thermally stabilized oxaloacetate, and150mg is vitamin C.
Shelf Life: 2 years
Note: Vitamin C is not just a filler: it's a key ingredient. Vitamin C acts as an electron acceptor, stabilizing the oxaloacetate and unlocking its full potential.
How Oxaloacetate Gives You The Advantages of Caloric Restriction (without restricting calories)
Oxaloacetate is a calorie restriction mimetic. It takes advantage of the benefits of calorie restriction while saving you from the negatives. In animals, calorie restriction can extend lifespan by up to 50%.
There is little question calorie restriction extends life in animals, but it can cause problems for humans like low body temperature, muscle loss, cognitive dysfunction, and decreased quality of life. This dilemma has led researchers to look for substances that mimic the effects of calorie restriction, while avoiding the side effects.
Oxaloacetate is the most promising substance we’ve yet found. It extends lifespan in worms and rodent by triggering the same effects as caloric restriction. By miming caloric restriction without its harmful effects, oxaloacetate has a plethora of health benefits, many of which we are just beginning to understand.
It programs genes for a longer life, it shields neurons from harmful amounts of glutamate, it protects mitochondria from DNA damage due to environmental toxins, and it may even help with age-related conditions. How Oxaloacetate Programs Your Genes for Maximum Longevity
Animal models show that oxaloacetate tells genes to keep you alive longer than would normally be possible. Activating the AMPK-FOXO pathways through calorie restriction extends lifespan in worms. In vitro, oxaloacetate can increase NAD+ levels by 50%, which activates the AMPK-FOXO pathways. Oxaloacetate tells your genes to make you live longer. Why Your Brain is in Danger (and How Oxaloacetate Can Help)
Oxaloacetate maintains healthy neurons in your brain and nervous system by insuring that there is no toxic build-up of glutamate in your head.
Glutamate is the most common neurotransmitter in your body. Monosodium glutamate (MSG) also raises glutamate levels in the human body. It is needed for learning and memory, but under the wrong conditions, it can kill neurons.
In excess, glutamate excites your brain cells to death, which can lead to serious problems including cognitive decline. In particular, glutamate kills the cells that make myelin, the coating around your nerves that is needed for the creation of white matter.
When everything is working right, glutamate levels in the brain are kept in a fine balance, with just enough being produced to support brain function without causing harm. However, chronic stress impairs glutamate metabolism so that excess glutamate accumulates in the brain.
Over time, excess glutamate can cause mental impairment, sleep problems, and even more stress, all of which impairs glutamate recycling. This becomes a vicious cycle where stress leads to glutamate toxicity, and glutamate toxicity leads to more stress. Oxaloacetate can stop this cycle from continuing and allow continued normal functioning. How Oxaloacetate Protects You From Brain Damage
Oxaloacetate steps in and keeps glutamate from wreaking havoc on your brain. Not only does it reduce glutamate levels, it converts the harmful excess glutamate into fuel for neurons.
Injecting rats with oxaloacetate also reduced glutamate levels and protected neurons after traumatic head injury. This results in improved brain function over the long term. On the flip side, when oxaloacetate metabolism is blocked in animals that suffer a stroke, brain damage is far more severe.
While the above research was done in animals - and we absolutely don’t recommend oxaloacetate for traumatic head injury or stroke - we think you can agree that this supplement is moving things in the right direction.
Oxaloacetate is water soluble, so it reaches almost every part of your body – including the inside of your brain.
Oxaloacetate show a lot of promise for maintaining proper neurological support. For our purposes, it's used to clear out brain fog that can occur from stress accumulated glutamate buildup. Thoughts are "smoother" and it lowers anxiety level to allow for better decisions.
In short, oxaloacetate keeps your brain on the right course, and provides neurological system support. It allows you think better, but oxaloacetate supports more than just brain cells. How Oxaloacetate Supports Your Mitochondria
Damage to mitochondrial DNA is a major contributor to aging and other serious conditions. Loss of brain function is often preceded by a decline in mitochondrial function.
In vitro studies have shown that oxaloacetate protects against mitochondrial DNA damage from environmental toxins.32 Oxaloacetate also supports your DNA by increasing NAD+ levels in your cells, which shields DNA from free radical damage. In rats, oxaloacetate can reduce mitochondrial damage caused by excitotoxins.
Oxaloacetate has also been shown to increase the protective effects of zinc on human eye cells in a test tube.35 By supporting your DNA and other tissues, oxaloacetate may reduce your risk of many age-related degenerative conditions.
If you want to learn more about oxaloacetate, check out some of our sources below! http://www.ncbi.nlm.nih.gov/pubmed/21402069 http://www.ncbi.nlm.nih.gov/pubmed/21411859 http://www.ncbi.nlm.nih.gov/pubmed/20698791 http://www.ncbi.nlm.nih.gov/pubmed/18277179 http://www.ncbi.nlm.nih.gov/pubmed/21841020 http://www.ncbi.nlm.nih.gov/pubmed/21840335 http://www.ncbi.nlm.nih.gov/pubmed/16626389 http://www.ncbi.nlm.nih.gov/pubmed/15247056 http://www.ncbi.nlm.nih.gov/pubmed/16399906 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078680 http://www.ncbi.nlm.nih.gov/pubmed/19793063 http://www.benthamscience.com/open/tolsj/articles/V003/SI0016TOLSJ/22TOLSJ.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/17900900 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1198718 http://www.ncbi.nlm.nih.gov/pubmed/10736372 http://www.ncbi.nlm.nih.gov/pubmed/7870979 http://www.ncbi.nlm.nih.gov/pubmed/16078441 http://www.ncbi.nlm.nih.gov/pubmed/21250988 http://www.ncbi.nlm.nih.gov/pubmed/8728878http://www.nature.com/nrn/journal/v13/n1/pdf/nrn3138.pdf?WT.ec_id=NRN-201201http://www.ncbi.nlm.nih.gov/pubmed/17014847 http://www.ncbi.nlm.nih.gov/pubmed/21361730 http://www.ncbi.nlm.nih.gov/pubmed/19259807 http://www.ncbi.nlm.nih.gov/pubmed/22129535 http://www.ncbi.nlm.nih.gov/pubmed/19543002 http://www.ncbi.nlm.nih.gov/pubmed/19135048 http://www.ncbi.nlm.nih.gov/pubmed/21266983 http://www.ncbi.nlm.nih.gov/pubmed/22085530 http://www.ncbi.nlm.nih.gov/pubmed/21265738 http://www.ncbi.nlm.nih.gov/pubmed/21266984 http://www.ncbi.nlm.nih.gov/pubmed/4884771 http://www.jbc.org/content/261/10/4535.abstract http://www.ncbi.nlm.nih.gov/pubmed/17344189 http://www.ncbi.nlm.nih.gov/pubmed/11592124http://www.ncbi.nlm.nih.gov/pubmed/14570397http://www.ncbi.nlm.nih.gov/pubmed/17487066