Are you working to reduce fatigue, anxiety, and brain fog? Do you want your thoughts to be smoother and more productive? Do you want to supercharge your brain for better learning and faster thinking without the side effects of stimulants? That’s a big part of learning to be in the Bulletproof state of high performance. It’s something we strive for every day, always seeking new ways to do more.
After years of testing, Upgraded Self is excited to introduce a new substance that has risen above the rest as a safe, effective way to Bulletproof your brain: oxaloacetate, also known as OAA.
Shown to protect neurons in the brain from environmental toxins, OAA can also improve day-to-day brain function and may even help reduce age related conditions. There is also compelling evidence that it can improve short term memory, as well as increasing the quantity and quality of life. (+)
Oxaloacetate is an anti-aging formula every Bulletproof person should consider for quality and length of life. Here’s why:
- It’s a nutritional supplement, not a drug. Oxaloacetate is found in many foods, and it’s a critical metabolic compound in your body.
- A lot of scientifically verified research.
- Our main recommendation for oxaloacetate is: support brain health, clear brain fog, stop repetitive/circular thoughts, and optimize clear cognitive potential. (+)
Our oxaloacetate is an extremely high quality product free of impurities, fillers and stabilizers. It is also thermally stabilized, you don’t have to store it at -40 degrees C.(+)
Upgraded Aging Formula vegi-caps are 100%soy-free, gluten-free, sugar-free, and contain no colorants, no flow agents, and no preservatives. (+)
Our Oxaloacetate is in a form that is easily assimilated - PKA studies show it in the bloodstream approximately 30 minutes after ingestion. (+)
Our main recommendation for oxaloacetate is: support brain health, clear brain fog, stop repetitive/circular thoughts, and optimize clear cognitive potential. (+) There are 250mg of Upgraded Aging Formula in each capsule, and 30 capsules in 1 bottle. 100mg of each capsule is thermally stabilized oxaloacetate, and150mg is vitamin C.
Shelf Life: 2 years
Note: Vitamin C is not just a filler: it's a key ingredient. Vitamin C acts as an electron acceptor, stabilizing the oxaloacetate and unlocking its full potential. (+)
If you are 18 years or younger, pregnant or lactating, on medication (including blood pressure medication), have a medical condition, or are allergic to any listed ingredients, please consult your health care practitioner before using this product. Do not use if safety seal is broken or missing.
If you have suffered tramatic head injury or stroke, please consult with your license health care provider before taking this product.
Oxaloacetate Gives You The Advantages of Caloric Restriction (without restricting calories)
Oxaloacetate is a calorie restriction mimetic. It takes advantage of the benefits of calorie restriction while saving you from the negatives. In animals, calorie restriction can extend lifespan by up to 50%. (+)
There is little question calorie restriction extends life in animals, but it can cause problems for humans like low body temperature, muscle loss, cognitive dysfunction, and decreased quality of life. This dilemma has led researchers to look for substances that mimic the effects of calorie restriction, while avoiding the side effects.
Oxaloacetate is the most promising substance we’ve yet found. It extends lifespan in worms and rodents by triggering the same effects as caloric restriction. By mimicing caloric restriction without its harmful effects, oxaloacetate has a plethora of health benefits, many of which we are just beginning to understand. (+)
Oxaloacetate is thought to work by protecting neurons from harmful amounts of glutamate, and protecting mitochondria from DNA damage due to environmental toxins. Oxaloacetate may also support health in age-related conditions.(+) Oxaloacetate Programs Your Genes for Maximum Longevity
Animal models show that oxaloacetate tells genes to keep you alive longer than would normally be possible. Activating the AMPK-FOXO pathways through calorie restriction extends lifespan in worms. In vitro, oxaloacetate can increase NAD+ levels by 50%, which activates the AMPK-FOXO pathways. Oxaloacetate may potentially support an increase lifespan. (+) Why Your Brain is in Danger (and How Oxaloacetate Can Help)
Oxaloacetate maintains healthy neurons in your brain and nervous system by insuring that there is no toxic build-up of glutamate in your head.(+)
Glutamate is the most common neurotransmitter in your body. Monosodium glutamate (MSG) also raises glutamate levels in the human body. It is needed for learning and memory, but under the wrong conditions, it can kill neurons.(+)
In excess, glutamate excites your brain cells to death, which can lead to serious problems including cognitive decline. In particular, glutamate kills the cells that make myelin, the coating around your nerves that is needed for the creation of white matter. (+)
When everything is working right, glutamate levels in the brain are kept in a fine balance, with just enough being produced to support brain function without causing harm. However, chronic stress impairs glutamate metabolism so that excess glutamate accumulates in the brain.(+)
Over time, excess glutamate can cause mental impairment, sleep problems, and even more stress, all of which impairs glutamate recycling. This becomes a vicious cycle where stress leads to glutamate toxicity, and glutamate toxicity leads to more stress. Oxaloacetate supports healthy glutamate metabolism, supporting appropriate brain function.(+) Oxaloacetate Protects You From Brain Damage
Oxaloacetate steps in and keeps glutamate from wreaking havoc on your brain. Not only does it reduce glutamate levels, it converts the harmful excess glutamate into fuel for neurons.(+)
Injecting rats with oxaloacetate also reduced glutamate levels and protected neurons after traumatic head injury. This results in improved brain function over the long term. On the flip side, when oxaloacetate metabolism is blocked in animals that suffer a stroke, brain damage is far more severe. (+)
Even though most studies on Oxaloacetate are done in animal studies, Oxaloacetate shows a lot of promise for supporting and maintaining proper neurological function. For our purposes, we use it to clear brain fog that can result from stress and glutamate buildup, and provide neurological support for smoother thought processes and performance. Please remember to consult with your licensed healthcare provider, first, before taking this product if you have had a traumatic head injury or have suffered a stroke.(+)Oxaloacetate Supports Your Mitochondria
Damage to mitochondrial DNA is a major contributor to aging and other serious conditions. Loss of brain function is often preceded by a decline in mitochondrial function. (+)
In vitro studies have shown that oxaloacetate protects against mitochondrial DNA damage from environmental toxins. Oxaloacetate also supports your DNA by increasing NAD+ levels in your cells, which shields DNA from free radical damage. In rats, oxaloacetate can reduce mitochondrial damage caused by excitotoxins.(+)
Oxaloacetate has also been shown to increase the protective effects of zinc on human eye cells in a test tube. By supporting your DNA and other tissues, oxaloacetate may reduce your risk of many age-related degenerative conditions. (+)If you want to learn more about oxaloacetate, check out some of our sources below!
If you want to learn more about oxaloacetate, check out some of our sources below! http://www.ncbi.nlm.nih.gov/pubmed/21402069 http://www.ncbi.nlm.nih.gov/pubmed/21411859 http://www.ncbi.nlm.nih.gov/pubmed/20698791 http://www.ncbi.nlm.nih.gov/pubmed/18277179 http://www.ncbi.nlm.nih.gov/pubmed/21841020 http://www.ncbi.nlm.nih.gov/pubmed/21840335 http://www.ncbi.nlm.nih.gov/pubmed/16626389 http://www.ncbi.nlm.nih.gov/pubmed/15247056 http://www.ncbi.nlm.nih.gov/pubmed/16399906 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078680 http://www.ncbi.nlm.nih.gov/pubmed/19793063 http://www.benthamscience.com/open/tolsj/articles/V003/SI0016TOLSJ/22TOLSJ.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/17900900 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1198718 http://www.ncbi.nlm.nih.gov/pubmed/10736372 http://www.ncbi.nlm.nih.gov/pubmed/7870979 http://www.ncbi.nlm.nih.gov/pubmed/16078441 http://www.ncbi.nlm.nih.gov/pubmed/21250988 http://www.ncbi.nlm.nih.gov/pubmed/8728878http://www.nature.com/nrn/journal/v13/n1/pdf/nrn3138.pdf?WT.ec_id=NRN-201201http://www.ncbi.nlm.nih.gov/pubmed/17014847 http://www.ncbi.nlm.nih.gov/pubmed/21361730 http://www.ncbi.nlm.nih.gov/pubmed/19259807 http://www.ncbi.nlm.nih.gov/pubmed/22129535 http://www.ncbi.nlm.nih.gov/pubmed/19543002 http://www.ncbi.nlm.nih.gov/pubmed/19135048 http://www.ncbi.nlm.nih.gov/pubmed/21266983 http://www.ncbi.nlm.nih.gov/pubmed/22085530 http://www.ncbi.nlm.nih.gov/pubmed/21265738 http://www.ncbi.nlm.nih.gov/pubmed/21266984 http://www.ncbi.nlm.nih.gov/pubmed/4884771 http://www.jbc.org/content/261/10/4535.abstract http://www.ncbi.nlm.nih.gov/pubmed/17344189 http://www.ncbi.nlm.nih.gov/pubmed/11592124http://www.ncbi.nlm.nih.gov/pubmed/14570397http://www.ncbi.nlm.nih.gov/pubmed/17487066